This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zammiti, W. Articles by Mahjoub, T. Search for Related Content PubMed PubMed Citation Articles by Zammiti, W. Articles by Mahjoub, T.

A case-control study on the association of idiopathic recurrent pregnancy loss with autoantibodies against ß2-glycoprotein I and annexin V

Laboratory of Hematology, Faculty of Pharmacy, University of Monastir, Tunisia, ¹ University of Montpellier, Montpellier, France, ² Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, P O Box 22979, Manama, Bahrain

Correspondence should be addressed to W Y Almawi; Email: wyalmawi{at}yahoo.co.uk

Whereas antiphospholipid antibodies (aPL) are associated with thrombotic events and recurrent spontaneous abortion (RSA), the contribution of anti-ß2 glycoprotein 1 (ß2GP1) and anti-annexin V antibodies as risk factors for RSA remain poorly understood. We investigated anti-ß2-GPI and anti-annexin V IgM and IgG antibodies as potential risk factors for RSA in 200 women with more than three consecutive idiopathic RSA, and 200 age-matched, healthy, parous women. Pearson’s chi squared test analysis showed that while anti-ß2-GPI IgG (P = 0.416) and IgM (P = 0.72) were comparable between patients and controls, elevated anti-annexin V IgG (P = 0.006), but not IgM (P = 0.084), was more pronounced in patients. Higher frequencies of elevated IgG-only (P = 0.005), but not IgM-only (P = 1.000; OR = 6.66), anti-annexin V antibodies were noted among patients. Multinomial regression analysis showed that body-mass index (overweight and obesity; P = 0.008), education status (P < 0.001) and anti-ß2-GPI IgM (P = 0.033), but not IgG (P = 0.723), were associated with early abortion, while anti-ß2-GPI IgG (P = 0.030) and anti-annexin V IgG (P = 0.004) were associated with late RSA. For combined early-late RSA, the only variable selected was education status (P < 0.001), and neither anti-annexin V nor anti-ß2-GPI IgM and IgG was associated with early-late RSA. Accordingly, anti-annexin V and anti-ß2-GPI should be regarded as independent risk markers of RSA.

This article has been cited by other articles:

				W. Zammiti, N. Mtiraoui, E. Cochery-Nouvellon, T. Mahjoub, W.Y. Almawi, and J.-C. Gris Association of -592C/A, -819C/T and -1082A/G interleukin-10 promoter polymorphisms with idiopathic recurrent spontaneous abortion Mol. Hum. Reprod., December 1, 2006; 12(12): 771 - 776. [Abstract] [Full Text] [PDF]