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Department of Internal Medicine and 1 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Correspondence should be addressed to J A Visser; Email: j.visser{at}erasmusmc.nl
Anti-Müllerian hormone (AMH) is a member of the transforming growth factor ß family of growth and differentiation factors. In the ovary, AMH has an inhibitory effect on primordial follicle recruitment as well as on the responsiveness of growing follicles to follicle-stimulating hormone (FSH). The ovary-specific expression pattern in granulosa cells of growing nonselected follicles makes AMH an ideal marker for the size of the ovarian follicle pool. This review summarizes recent findings concerning AMH and its role as a marker for the quantitative aspect of ovarian reserve as well as ovarian dysfunction.
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