This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kimber, S. J Search for Related Content PubMed PubMed Citation Articles by Kimber, S. J

Leukaemia inhibitory factor in implantation and uterine biology

Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK

Correspondence should be addressed to S J Kimber; Email: sue.kimber{at}manchester.ac.uk

Leukaemia inhibitory factor (LIF) is one of the most important cytokines in the reproductive tract. Without expression of LIF in the uterus, implantation of a blastocyst cannot begin. Yet, 13 years after publication of the phenotype of the LIF knockout mouse we are only just beginning to understand how LIF functions in the uterus. This review addresses our knowledge of the role of LIF in regulating implantation through its influence on the luminal epithelium and stromal decidualization, but also its influence on reproductive tract cells such as leukocytes and glandular epithelium, during the pre-implantation phase of pregnancy.

This article has been cited by other articles:

				C.E. Quinn and R.F. Casper Pinopodes: a questionable role in endometrial receptivity Hum. Reprod. Update, March 1, 2009; 15(2): 229 - 236. [Abstract] [Full Text] [PDF]

				G. Song, M C. Satterfield, J. Kim, F. W Bazer, and T. E Spencer Progesterone and interferon tau regulate leukemia inhibitory factor receptor and IL6ST in the ovine uterus during early pregnancy Reproduction, March 1, 2009; 137(3): 553 - 565. [Abstract] [Full Text] [PDF]

				M. S. M. van Mourik, N. S. Macklon, and C. J. Heijnen Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment J. Leukoc. Biol., January 1, 2009; 85(1): 4 - 19. [Abstract] [Full Text] [PDF]

				A. Tapia, L. A. Salamonsen, U. Manuelpillai, and E. Dimitriadis Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2 Hum. Reprod., August 1, 2008; 23(8): 1724 - 1732. [Abstract] [Full Text] [PDF]

				A.A Fouladi-Nashta, L Mohamet, J.K Heath, and S.J Kimber Interleukin 1 Signaling Is Regulated by Leukemia Inhibitory Factor (LIF) and Is Aberrant in Lif-/- Mouse Uterus Biol Reprod, July 1, 2008; 79(1): 142 - 153. [Abstract] [Full Text] [PDF]

				S J Kimber, S F Sneddon, D J Bloor, A M El-Bareg, J A Hawkhead, A D Metcalfe, F D Houghton, H J Leese, A Rutherford, B A Lieberman, et al. Expression of genes involved in early cell fate decisions in human embryos and their regulation by growth factors Reproduction, May 1, 2008; 135(5): 635 - 647. [Abstract] [Full Text] [PDF]

				J.-W. Xu, N. Yasui, K. Ikeda, W.-J. Pan, J. Watanabe, M. Shiotani, A. Yanaihara, T. Miki, and Y. Yamori Isoflavones regulate secretion of leukemia inhibitory factor and transforming growth factor {beta} and expression of glycodelin in human endometrial epithelial cells J. Endocrinol., February 1, 2008; 196(2): 425 - 433. [Abstract] [Full Text] [PDF]

				R. G Lea and O. Sandra Immunoendocrine aspects of endometrial function and implantation Reproduction, September 1, 2007; 134(3): 389 - 404. [Abstract] [Full Text] [PDF]

				K. Diedrich, B.C.J.M. Fauser, P. Devroey, G. Griesinger, and on behalf of the Evian Annual Reproduction (EVAR) The role of the endometrium and embryo in human implantation Hum. Reprod. Update, July 1, 2007; 13(4): 365 - 377. [Abstract] [Full Text] [PDF]

				H. Horita, E. Kuroda, T. Hachisuga, M. Kashimura, and U. Yamashita Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo Hum. Reprod., July 1, 2007; 22(7): 1801 - 1809. [Abstract] [Full Text] [PDF]

				M. Torricelli, G. De Falco, P. Florio, M. Rossi, E. Leucci, P. Vigano, L. Leoncini, and F. Petraglia Secretory endometrium highly expresses urocortin messenger RNA and peptide: possible role in the decidualization process Hum. Reprod., January 1, 2007; 22(1): 92 - 96. [Abstract] [Full Text] [PDF]

				N. Underhill-Day and J. K. Heath Oncostatin M (OSM) Cytostasis of Breast Tumor Cells: Characterization of an OSM Receptor {beta}-Specific Kernel. Cancer Res., November 15, 2006; 66(22): 10891 - 10901. [Abstract] [Full Text] [PDF]