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Reproduction (2005) 129 531-534
DOI: 10.1530/rep.1.00567
Copyright © 2005 Society for Reproduction and Fertility
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RESEARCH

Estradiol and leptin as conditional prognostic IVF markers

G Anifandis1, E Koutselini1, K Louridas1, V Liakopoulos1, K Leivaditis1, T Mantzavinos1, D Sioutopoulou1 and N Vamvakopoulos2

1 Department of Biology & Genetics of Larissa, University of Thessalia Medical School, 22 Papakyriazi, Larisa 41222, Larissa, Greece and 2 2nd Department of Obstetrics and Gynecology of Athens, University of Athens, Aretaieio hospital, 76 V. Sofias Ave, 11528, Athens, Greece

Correspondence should be addressed to Anifandis Georgios; Email: ganif{at}med.uth.gr

We studied the concentration of serum estradiol and serum and follicular fluid leptin in 200 women undergoing their first in vitro fertilization with embryo transfer (IVF-ET) program at the time of human chorionic gonadotrophin administration and oocyte retrieval, in an attempt to assess their concerted role on embryo quality and the prognosis of IVF outcome. Low serum (46.49 ± 8.4 ng/ml) and follicular fluid (52 ± 9.8 ng/ml) leptin levels were associated with a high number of ‘good-quality’ embryos (73.6%) and high implantation (11.2%) and pregnancy (35.8%) rates and were observed in women with normal peak estradiol levels of between 1000 and 2000 pg/ml. It appears that leptin and estradiol interact coordinately in a concentration-dependent manner to control IVF outcome. Further studies will be required to substantiate and clarify the mechanism of proposed conditional interaction between the two hormonal systems.




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