| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Articles |
Preimplantation embryonic development is associated with a change in preference in energy metabolism pathways. Although oxidative phosphorylation is obligatory in most species throughout preimplantation development, an increasing role for energy derived from glycolysis is associated with compaction and blastulation. Such a shift in metabolic pathway preference is desirable as the embryo faces an increasingly hypoxic environment in utero. We hypothesize that this shift in metabolic preference is associated with a change in the reduction-oxidation (REDOX) state within the embryo, affecting not only the energy production required for development, but also the activity of REDOX-sensitive transcription factors, which may alter gene expression patterns. Shifts in intracellular REDOX state may also contribute to spatial differences in cell activity, especially after compaction, and perhaps even major embryonic events such as fertilization, genome activation and cellular differentiation.
This article has been cited by other articles:
 |
|
 |
|
  D.H. Betts and P. Madan Permanent embryo arrest: molecular and cellular concepts Mol. Hum. Reprod., August 1, 2008; 14(8): 445 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.J. Harvey, K.L. Kind, and J.G. Thompson Regulation of Gene Expression in Bovine Blastocysts in Response to Oxygen and the Iron Chelator Desferrioxamine Biol Reprod, July 1, 2007; 77(1): 93 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.S. Lopes, S.E. Madsen, N.B. Ramsing, P. Lovendahl, T. Greve, and H. Callesen Investigation of respiration of individual bovine embryos produced in vivo and in vitro and correlation with viability following transfer Hum. Reprod., February 1, 2007; 22(2): 558 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Vitalini, R. M. de Paula, W. D. Park, and D. Bell-Pedersen The Rhythms of Life: Circadian Output Pathways in Neurospora. J Biol Rhythms, December 1, 2006; 21(6): 432 - 444. [Abstract] [PDF]
|
|
|
|
 |
|
 A R Clark, Y M Stokes, M Lane, and J G Thompson Mathematical modelling of oxygen concentration in bovine and murine cumulus-oocyte complexes. Reproduction, June 1, 2006; 131(6): 999 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R Herrick, A. M Brad, and R. L Krisher Chemical manipulation of glucose metabolism in porcine oocytes: effects on nuclear and cytoplasmic maturation in vitro Reproduction, February 1, 2006; 131(2): 289 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A S Lopes, L H Larsen, N Ramsing, P Lovendahl, M Raty, J Peippo, T Greve, and H Callesen Respiration rates of individual bovine in vitro-produced embryos measured with a novel, non-invasive and highly sensitive microsensor system Reproduction, November 1, 2005; 130(5): 669 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Thouas, A. O. Trounson, and G. M. Jones Effect of Female Age on Mouse Oocyte Developmental Competence Following Mitochondrial Injury Biol Reprod, August 1, 2005; 73(2): 366 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lapointe, S. Kimmins, L. A. MacLaren, and J.-F. Bilodeau Estrogen Selectively Up-Regulates the Phospholipid Hydroperoxide Glutathione Peroxidase in the Oviducts Endocrinology, June 1, 2005; 146(6): 2583 - 2592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. O'Neill The role of paf in embryo physiology Hum. Reprod. Update, May 1, 2005; 11(3): 215 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M Orsi, N. Gopichandran, H. J Leese, H. M Picton, and S. E Harris Fluctuations in bovine ovarian follicular fluid composition throughout the oestrous cycle Reproduction, February 1, 2005; 129(2): 219 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Leyens, B. Verhaeghe, M. Landtmeters, J. Marchandise, B. Knoops, and I. Donnay Peroxiredoxin 6 Is Upregulated in Bovine Oocytes and Cumulus Cells During In Vitro Maturation: Role of Intercellular Communication Biol Reprod, November 1, 2004; 71(5): 1646 - 1651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.J. Harvey, K.L. Kind, M. Pantaleon, D.T. Armstrong, and J.G. Thompson Oxygen-Regulated Gene Expression in Bovine Blastocysts Biol Reprod, October 1, 2004; 71(4): 1108 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Dumollard, P. Marangos, G. Fitzharris, K. Swann, M. Duchen, and J. Carroll Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production Development, July 1, 2004; 131(13): 3057 - 3067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Krisher The effect of oocyte quality on development J Anim Sci, January 1, 2004; 82(13_suppl): E14 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rizos, A. Gutierrez-Adan, S. Perez-Garnelo, J. de la Fuente, M.P. Boland, and P. Lonergan Bovine Embryo Culture in the Presence or Absence of Serum: Implications for Blastocyst Development, Cryotolerance, and Messenger RNA Expression Biol Reprod, January 1, 2003; 68(1): 236 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Thompson, K. L. Kind, C. T. Roberts, S. A. Robertson, and J. S. Robinson Epigenetic risks related to assisted reproductive technologies: Short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution? Hum. Reprod., November 1, 2002; 17(11): 2783 - 2786. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
