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The influence of the time of spaying on the occurrence of delayed implantation has been intensively studied in the rat. Although it was originally reported that early spaying (Day 1 or 2 of pregnancy) followed by progesterone treatment did not lead to a delay in implantation, whereas spaying at a later stage (Day 4) did (Canivenc, Laffargue & Mayer, 1956; Cochrane & Meyer, 1957), further work on rats revealed that spaying before Day 4 generally resulted in delayed implantation (Psychoyos & Alloiteau, 1962; Nutting & Meyer, 1963; Mayer, 1963). Failure to observe delayed implantation more universally in the early experiments has been ascribed in part to incomplete ovariectomy. As the influence of the time of spaying on implantation has apparently not been examined in the adult mouse, the present work was undertaken. Endocrinolo
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H. Lim and S. K. Dey Prostaglandin E2 Receptor Subtype EP2 Gene Expression in the Mouse Uterus Coincides with Differentiation of the Luminal Epithelium for Implantation Endocrinology, November 1, 1997; 138(11): 4599 - 4606. [Abstract] [Full Text] [PDF]
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G. Benson, H Lim, B. Paria, I Satokata, S. Dey, and R. Maas Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression Development, January 9, 1996; 122(9): 2687 - 2696. [Abstract] [PDF]
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G Raab, K Kover, B. Paria, S. Dey, R. Ezzell, and M Klagsbrun Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor Development, January 2, 1996; 122(2): 637 - 645. [Abstract] [PDF]
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S. Das, X. Wang, B. Paria, D Damm, J. Abraham, M Klagsbrun, G. Andrews, and S. Dey Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation Development, January 5, 1994; 120(5): 1071 - 1083. [Abstract] [PDF]
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