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TENTATIVE IDENTIFICATION OF PLASMA, OVARIAN AND PLACENTAL OESTROGENS IN THE GUINEA-PIG

Following development of more accurate and sensitive chemical and physical identification techniques for oestrogen determinations, many species have been studied. Since 1955 oestrogenic steroids have been identified in at least twenty-five species of animals. In our laboratory, the dog (Metzler, Eleftheriou & Fox, 1966), the channel catfish (Eleftheriou, Boehlke & Tiemeier, 1966a) and the deer (Eleftheriou, Boehlke, Zolovick & Knowlton, 1966b) have been studied.

The oestrogen picture has been notably inconsistent as to types of oestrogens produced in various species and to quantitative levels maintained in the blood, ovary and placenta. Although oestradiol-17β seems to be the major oestrogen in most of the species examined, there is no observed pattern in either oestrogen types or levels of circulating oestrogen metabolites in the blood within the animal kingdom. Studies reported here attempted to identify the oestrogens in the plasma, ovary and placenta of the laboratory guinea-pig and to quantitate these oestrogens using a fluorometric technique.