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Termination of obligate anoestrus and induction of fertile ovarian cycles in dogs by administration of purified pig LH

The potential role of LH in the initiation of the follicular phase in dogs was investigated by treating anoestrous bitches with highly purified pig LH (n = 16) or saline (n = 8) three times a day for 7 days, beginning in either early anoestrus (days 94–116 of the cycle) or midanoestrus (days 124–145). Treatment with LH induced pro-oestrus within 7 days (n = 16), and oestrus (n = 12) and fertile ovulations (n = 7) at 16 + 3 days, while pro-oestrus in bitches treated with saline did not occur until 46–166 days after the start of treatment. Six of the seven ovulating bitches whelped normal litters. The bitches in which pro-oestrus but not oestrus occurred were all treated in early anoestrus. During treatment, plasma oestradiol in bitches treated with LH increased from 8 + 2 pg ml^–1 to 20 + 5 pg ml^–1 within 1 day, and reached higher peak values (45 + 7 pg ml^–1) (P < 0.05) than those observed in saline-treated controls (9 + 3 ng ml^–1). These results demonstrate that LH treatment alone can terminate anoestrus by inducing a normal follicular phase in dogs. The results also suggest that, in normal cyclic bitches, anoestrus is the result of insufficient LH secretion, and that spontaneous pro-oestrus could be the result of increased LH secretion in the presence of already adequate concentrations of FSH.

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