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Comparative study between pony mares and ewes evaluating gonadotrophic response to administration of gonadotrophin-releasing hormone

This study compared equine and ovine LH secretory responses to GnRH treatment. Dioestrous mares and ewes were challenged with continuous GnRH for 15 h. Mares that received constant GnRH (110 µg h^–1) had sustained LH secretion P <0.01), whereas LH concentrations in ewes treated with continuous GnRH (25 µg h^–1) initially increased, then declined and remained low, suggesting GnRH receptor desensitization or downregulation. In addition, progesterone-primed, ovariectomized mares and ewes were challenged with pulsatile or continuous GnRH for 5 days. Plasma LH concentrations were increased by day 5 in mares treated with pulsatile (25 µg pulse^–1 h^–1) and continuous (110 µg h^–1) GnRH (P < 0.01). Furthermore, mean LH concentrations and time–response curves were not different. In contrast, ewes treated with continuous GnRH (2.5 µg h^–1) demonstrated LH secretory patterns indicative of GnRH receptor downregulation on day 1 of treatment. LH concentrations in ewes treated with pulsatile GnRH (250 ng pulse^–1 h^–1) did not differ from controls. In conclusion, pony mares responded continuously to GnRH treatment (pulsatile and continuous), whereas ewes treated with continuous GnRH experienced reduced LH secretion. These findings suggest a unique hypothalamic–pituitary axis in pony mares.